Multicentre Randomized Double-Blinded Trial of Intrapleural Dornase Alfa and Urokinase vs Urokinase Alone for Complicated Parapneumonic Effusions in Children (DUKE)

NCT00502632 Phase 2/Phase 3 UNKNOWN

The purpose of this study is to determine whether intrapleural treatment with Dornase alfa plus Urokinase improves clinical outcome compared to Urokinase alone in children with complicated parapneumonic effusions

Details

Lead sponsor	Azienda Ospedaliera di Padova
Phase	Phase 2/Phase 3
Status	UNKNOWN
Enrolment	94
Start date	2007-10
Completion	2009-10

Conditions

• Pleural Empyema

Interventions

• Urokinase and Dornase alfa
• Urokinase

Primary outcomes

• Duration of hospital stay — From beginning of intrapleural treatment
• Need for additional surgical procedures — 3 months

Countries

Italy