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Effect of Beta Blocker Treatment on Endothelial Function in Patients With Type 2 Diabetes or Chronic Heart Failure
The aim of this study is to evaluate the effect of the two different beta blockers metoprolol and carvedilol on endothelial function in patients with either type two diabetes or chronic heart failure. Hypothesis: 1\* Carvedilol compared to metoprolol has a favourable effect on endothelial function. 2\* Carvedilol compared to metoprolol has a favourable effect on insulin stimulated endothelial function. The study is conducted as an open parallel group study. Endothelial function and insulin stimulated endothelial function was evaluated before and after a two months treatment period with either of the two beta blockers.
Details
| Lead sponsor | Bispebjerg Hospital |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 50 |
| Start date | 2004-02 |
| Completion | 2007-10 |
Conditions
- Endothelial Function
- Beta Blocker
Interventions
- Treatment with either metoprolol or carvedilol
Primary outcomes
- Endothelial function and insulin stimulated endothelial function — 2 months
Countries
Denmark