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The Effects of 7 Days of Exogenous Pulsatile GnRH Treatment on the Pituitary-Gonadal Axis in Hypogonadotropic Hypogonadal Subjects
Men with Idiopathic Hypogonadotropic Hypogonadism (IHH) lack a hormone called gonadotropin releasing hormone (GnRH). This hormone is important for starting puberty, maintaining testosterone levels, and fertility. The purpose of this study is to research the effects of treating IHH men with GnRH for 7 days.
Details
| Lead sponsor | Massachusetts General Hospital |
|---|---|
| Phase | Phase 1 |
| Status | COMPLETED |
| Enrolment | 27 |
| Start date | 1999-01 |
| Completion | 2009-11-17 |
Conditions
- Kallmann Syndrome
- Idiopathic Hypogonadotropic Hypogonadism
- GnRH Deficiency
Interventions
- gonadotropin releasing hormone (GnRH)
Primary outcomes
- testosterone — daily for 7 days
- LH — frequent sampling for 2 hours
- FSH — frequent sampling for 2 hours
- Inhibin B — daily for 7 days
- free alpha subunit — daily for 7 days
Countries
United States