Peri-articular Injections Containing a Corticosteroid During Total Knee Arthroplasty

NCT00492973 NA COMPLETED Results posted

Prior to surgery, a pharmacist will randomly assign participating patients to one of two groups. One group will get an injection in the knee during surgery that contains medications to limit pain and an antibiotic. A second group will get an injection in the knee during surgery that contains the same pain medications and antibiotic along with a corticosteroid to control inflammation. Corticosteroids are anti-inflammatory medications, not to be confused with muscle-building anabolic steroids you may have heard about in the news. Each patient will have an equal chance of being in either of the two groups. This study will test the safety and efficacy of methylprednisolone acetate in the treatment of pain and inflammation following total knee replacement.

Details

Lead sponsor	New Lexington Clinic
Phase	NA
Status	COMPLETED
Enrolment	101
Start date	2006-03
Completion	2008-02

Conditions

• Osteoarthritis
• Post-traumatic; Arthrosis

Interventions

• methylprednisolone acetate
• active comparator

Primary outcomes

• Length of Hospital Stay — days after surgery
• Knee Range of Motion — 3 months
• Knee Society Scores — 3 months postoperative
  The Knee Society Score is on a scale of 0 to 100, with 0 being the worst possible score, and 100 being the best possible score. The Knee Society Score takes into account subjective patient reports of pain and functional ability as well as clinical measures of passive knee range of motion.
• Amount of Pain Medication Taken Per Day — Average of 3 days after surgery
• Patient Satisfaction — 6 weeks, 3 months, and 1 year postoperative
• Complications, Such as Infections, Hospital Readmissions, Manipulations Under Anesthesia, Etc. — any point during the first postoperative year

Countries

United States