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Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as temozolomide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with temozolomide may kill more tumor cells. It is not yet known whether radiation therapy and temozolomide are more effective than radiation therapy alone in treating glioblastoma multiforme. PURPOSE: This randomized phase III trial is studying radiation therapy and temozolomide to see how well they work compared with radiation therapy alone in treating patients with newly diagnosed glioblastoma multiforme.
Details
| Lead sponsor | Canadian Cancer Trials Group |
|---|---|
| Phase | PHASE3 |
| Status | COMPLETED |
| Enrolment | 562 |
| Start date | Wed Nov 14 2007 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed Aug 10 2016 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Brain and Central Nervous System Tumors
Interventions
- temozolomide
- DNA methylation analysis
- quality-of-life assessment
- Radiation
Countries
Netherlands, Canada, Japan, Germany