Who is sponsoring NCT00474838?

NCT00474838 is sponsored by Kyunghee University Medical Center.

What drugs are being tested in NCT00474838?

Interventions in NCT00474838: intensive insulin group, Oral AntiDiabetic Drug (glimepiride and metformin).

What condition does NCT00474838 study?

NCT00474838 studies Type 2 Diabetes Mellitus, Pancreatic Beta Cell Function, Glucotoxicity.

Is NCT00474838 still recruiting?

NCT00474838 is currently completed. Last updated 25 September 2013.

Last reviewed 2013-09-25 · How we verify

NCT00474838: KIIT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

The Effect of Intensive and Short-term Insulin Treatment on Long-term Pancreatic β-cell Function in Newly Diagnosed People With Type 2 Diabetes in Korea

Completed Phase 4 Last updated 25 September 2013

What this trial tests

Phase 4 trial testing intensive insulin group in Type 2 Diabetes Mellitus in 112 participants. Completed in 1 December 2012.

Timeline

1 April 2007

Primary endpoint
1 August 2012

1 December 2012

Quick facts

Lead sponsor	Kyunghee University Medical Center
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	112
Start date	1 April 2007
Primary completion	1 August 2012
Estimated completion	1 December 2012
Sites	8 locations across South Korea

Drugs / interventions tested

intensive insulin group — full drug profile →
Oral AntiDiabetic Drug (glimepiride and metformin) — full drug profile →

Conditions studied

Type 2 Diabetes Mellitus — all drugs for Type 2 Diabetes Mellitus →
Pancreatic Beta Cell Function — all drugs for Pancreatic Beta Cell Function →
Glucotoxicity — all drugs for Glucotoxicity →

Sponsor

Kyunghee University Medical Center

Who can join

Adults 25 to 70, any sex, with Type 2 Diabetes Mellitus or Pancreatic Beta Cell Function. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Long-term glycemic control
Time frame: up to 2 years
Change of pancreatic beta cell function
Time frame: up to 2 years

Sponsor's own description

This randomized controlled prospective study aims to evaluate the efficacy of intensive insulin therapy for long term glycemic control and improvement or preservation of beta cell function in newly diagnosed type 2 diabetes patients.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

The effect of early insulin therapy on pancreatic β-cell function and long-term glycemic control in newly diagnosed type 2 diabetic patients.
Chon S, Oh S, Kim SW, Kim JW, et al · · 2010 · cited 26× · PMID 20830224 · DOI 10.3904/kjim.2010.25.3.273
Hypoglycemia and Medical Expenses in Patients with Type 2 Diabetes Mellitus: An Analysis Based on the Korea National Diabetes Program Cohort.
Rhee SY, Hong SM, Chon S, Ahn KJ, et al · · 2016 · cited 16× · PMID 26890789 · DOI 10.1371/journal.pone.0148630
Abstracts of the 49th EASD (European Association for the Study of Diabetes) Annual Meeting. September 23-27, 2013. Barcelona, Spain.
· 2013 · cited 3× · PMID 23949610 · DOI 10.1007/s00125-013-3012-z

Verify or expand the search:

Other recruiting trials for Type 2 Diabetes Mellitus

Currently open trials in the same condition.

NCT07351058 — A Clinical Study to Evaluate the Effects of RO7795068 in Participants With Obesity or Overweight and Type 2 Diabetes · Phase 3 · recruiting
NCT07373938 — Carotid Wall Texture as a Cardiovascular Risk Biomarker in Type 2 Diabetes Mellitus · recruiting
NCT07433062 — A Study to Evaluate the Effect of AZD6793 on the Pharmacokinetics and Pharmacodynamics of Metformin in Participants With · Phase 1 · recruiting
NCT07276776 — An Evaluation of the Omnipod® M System in Adults With Type 2 Diabetes · NA · active not recruiting
NCT07232537 — An Observational Study Called FINE-REAL Korea to Learn More About the Use of the Drug Finerenone in People With Chronic · recruiting

Other Kyunghee University Medical Center trials

Trials by the same sponsor.

NCT06183697 — Multi-omics Database Construction of Healthy Korean Volunteers · recruiting
NCT06113497 — A Prospective Study on the Comparison of Postoperative Pain According to the Use of Cocktail Therapy in Laminoplasty · Phase 4 · unknown
NCT06049914 — Combined Exercise and Nutrition Intervention for Possible Sarcopenia Among Older Adults in Primary Care · NA · unknown
NCT03515070 — Microbiome and Genetic Analysis of Familial IBD · completed
NCT03589183 — Gut Microbiome in Inflammatory Bowel Disease · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00474838 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Kyunghee University Medical Center
Last refreshed: 25 September 2013

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00474838.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing