NCT00471523 is a Phase 4 clinical trial of Clomiphene citrate in Infertility, sponsored by University Magna Graecia.

Who is sponsoring NCT00471523?

NCT00471523 is sponsored by University Magna Graecia.

What drugs are being tested in NCT00471523?

Interventions in NCT00471523: Clomiphene citrate, Metformin.

What condition does NCT00471523 study?

NCT00471523 studies Infertility, Polycystic Ovary Syndrome, Anovulation.

Is NCT00471523 still recruiting?

NCT00471523 is currently completed. Last updated 8 May 2007.

Last reviewed 2007-05-08 · How we verify

NCT00471523

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clomiphene Citrate Versus Metformin as First-Line Approach for the Treatment of Anovulation in Infertile Patients With Polycystic Ovary Syndrome

Completed Phase 4 Last updated 8 May 2007

What this trial tests

Phase 4 trial testing Clomiphene citrate in Infertility in 80 participants. Completed in 1 March 2007.

Timeline

1 May 2006

1 March 2007

Quick facts

Lead sponsor	University Magna Graecia
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	non randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	80
Start date	1 May 2006
Estimated completion	1 March 2007
Sites	1 location across Italy

Drugs / interventions tested

Clomiphene citrate — full drug profile →
Metformin (metformin) — full drug profile →

Conditions studied

Infertility — all drugs for Infertility →
Polycystic Ovary Syndrome — all drugs for Polycystic Ovary Syndrome →
Anovulation — all drugs for Anovulation →

Sponsor

University Magna Graecia

Who can join

Adults 18 to 41, female only, with Infertility or Polycystic Ovary Syndrome. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Pregnancy rate
Time frame: 10 months

Sponsor's own description

Clomiphene citrate (CC) and metformin are two effective drugs used to induce ovulation in patients with polycystic ovary syndrome (PCOS), even if it is still unclear which compound between them should be initially administered. The aim of the study will be to compare in a clinical setting the efficacy of CC and metformin as first-line approaches for treating anovulation in infertile PCOS patients.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Recent trends in polycystic ovary syndrome treatment based on adult stem cell therapies.
Park H, Han JW, Kim GJ. · · 2025 · cited 1× · PMID 40114307 · DOI 10.5653/cerm.2024.07248

Verify or expand the search:

Other trials of Clomiphene citrate

Trials testing the same drug.

NCT02865681 — Protocol to Minimize Injections and Blood Draws for Women Undergoing in Vitro Fertilization · NA · completed

Other recruiting trials for Infertility

Currently open trials in the same condition.

NCT07074015 — IntelliWell: An AI-Assisted Imaging Platform for Detection and Location of Ultra-Rare Testicular Sperm in Surgical Speci · NA · recruiting
NCT07358468 — Impact Of FET Preparation Protocol On Endometrial Peristalsis: A Prospective Cohort Study · recruiting
NCT07340827 — A Study to Compare the Efficacy and Safety of Follitropin Alfa/Lutropin Alfa Versus hMG in Japanese Participants With LH · Phase 3 · recruiting
NCT07369362 — To Investigate if the Harvester® Improves Sperm Motility and Blastocyst Utilization (the Percent of Fertilized Eggs That · NA · active not recruiting
NCT07153367 — Using a Fixed Dosage of Follitropin Delta for Ovarian Stimulation for Intrauterine Insemination: Rekovelle for Intrauter · Phase 2 · recruiting

Other University Magna Graecia trials

Trials by the same sponsor.

NCT07173660 — Consensus Statements on Deep Brain Stimulation in Patients With Parkinson's Disease · not yet recruiting
NCT06830460 — Measurement of the Optic Nerve Diameter in Different Healthcare Operators · NA · not yet recruiting
NCT06274931 — Analysis of the Pulmonary Microbiome · unknown
NCT05398289 — FOUR-SIX TRIAL for the Treatment of Enterococcal Endocarditis · Phase 4 · not yet recruiting
NCT05681962 — Practice of Oxygenation and Respiratory Support During Fiberoptic Bronchoscopy · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00471523 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Magna Graecia
Last refreshed: 8 May 2007

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00471523.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing