NCT00450164 (KT-2000) is a Phase 4 clinical trial of esofagic varices ligation in Gastrointestinal Hemorrhage, sponsored by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau.

Who is sponsoring NCT00450164?

NCT00450164 is sponsored by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau.

What drugs are being tested in NCT00450164?

Interventions in NCT00450164: esofagic varices ligation, Nadolol, Isosorbide mononitrate, Prazosin.

What condition does NCT00450164 study?

NCT00450164 studies Gastrointestinal Hemorrhage, Portal Hypertension, Cirrhosis.

Is NCT00450164 still recruiting?

NCT00450164 is currently completed. Last updated 20 March 2007.

Last reviewed 2007-03-20 · How we verify

NCT00450164: KT-2000

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Secondary Prophylaxis After Variceal Bleeding: Combined Treatment With Endoscopic Ligation and Nadolol Against Nadolol Associated With Mononitrate of Isosorbide or Prazosin According to Hemodynamic Response.

Completed Phase 4 Last updated 20 March 2007

What this trial tests

Phase 4 trial testing esofagic varices ligation in Gastrointestinal Hemorrhage in 50 participants. Completed in 1 June 2004.

Timeline

1 November 2000

1 June 2004

Quick facts

Lead sponsor	Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	50
Start date	1 November 2000
Estimated completion	1 June 2004
Sites	1 location across Spain

Drugs / interventions tested

esofagic varices ligation
Nadolol (NADOLOL) — full drug profile →
Isosorbide mononitrate (ISOSORBIDE MONONITRATE) — full drug profile →
Prazosin (PRAZOSIN) — full drug profile →

Conditions studied

Gastrointestinal Hemorrhage — all drugs for Gastrointestinal Hemorrhage →
Portal Hypertension — all drugs for Portal Hypertension →
Cirrhosis — all drugs for Cirrhosis →

Sponsor

Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau

Who can join

Adults 18 to 80, any sex, with Gastrointestinal Hemorrhage or Portal Hypertension. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Compared efficacy (at least 6 moths of follow-up)

Sponsor's own description

Controlled and randomized study comparing combined treatment (nadolol and endoscopic ligation) versus nadolol associated with isosorbide mononitrate or prazosin according to hemodynamic response, in the prevention of esofagic verices rebleeding.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Gastrointestinal Hemorrhage

Currently open trials in the same condition.

NCT07002359 — Assessment of Laboratory Parameters and Imaging Findings in Patients With Gastrointestinal Bleeding · active not recruiting

Other Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau trials

Trials by the same sponsor.

NCT07343882 — Quantification of Systemic Congestion by Ultrasound As a Predictor of Weaning Failure From Mechanical Ventilation · NA · not yet recruiting
NCT07530237 — Efficacy of Periarticular Vasoconstrictor Infiltration (PVI) in Reducing Bleeding and Postoperative Pain in Lumbar Fusio · active not recruiting
NCT07369310 — Comparing Biomarker-Guided DBS Programming With Standard Clinical Monopolar Programming · NA · not yet recruiting
NCT07314190 — Retrospective Observational Study of Blood-based Biomarkers in the Diagnosis and Monitoring of Patients With a Neurodege · enrolling by invitation
NCT07239843 — Prospective Observational Study of the Relationship Between Sociodemographic Factors, Blood-based Biomarkers and Psychia · enrolling by invitation

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00450164 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Last refreshed: 20 March 2007

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00450164.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing