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A Randomized Trial of Early Discharge After Trans-Radial Stenting of Coronary Arteries in Acute Myocardial Infarction and RESCUE-PCI: The EASY-RESCUE Pilot Study
* Abciximab administration is safe and reduces ischemic complications in patients undergoing rescue PCI after failed thrombolysis compared to placebo. * Abciximab improves angiographic scores and ventricular function after rescue-PCI compared to placebo. * Intracoronary abciximab administration is more effective than intravenous route of administration in terms of acute and mid-term angiographic and clinical results. * Intracoronary and intravenous bolus administration of abciximab dose provides similar platelet aggregation inhibition (PAI). * There is a significant relationship between PAI after abciximab administration and indexes of myocardial perfusion. * Routine use of Sirolimus-eluting stents (Cypher, Cordis, US) in rescue-PCI is associated with a low rate of target vessel revascularization. * Cardiac MRI early and late after rescue-PCI provides detailed information on myocardial injury and irreversible necrosis, which are correlated with angiographic perfusion scores. * After uncomplicated trans-radial rescue PCI, patients can be retransferred early to their referring center.
Details
| Lead sponsor | Olivier F. Bertrand |
|---|---|
| Phase | Phase 4 |
| Status | COMPLETED |
| Enrolment | 74 |
| Start date | 2007-02 |
| Completion | 2013-05 |
Conditions
- Myocardial Infarction
- Ischemia
Interventions
- Abciximab
Primary outcomes
- TIMI score and myocardial blush grade after rescue-PCI at baseline and at 6-month follow-up — 6 months
Countries
Canada