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Effects of Treatment With Doxycycline and Rifampicin on Biomarkers of Alzheimer's Disease in the Cerebrospinal Fluid
This study will determine if biomarkers found in the cerebrospinal fluid of people with Alzheimer's disease, are affected by treatment with two common antibiotics, doxycycline and rifampicin, suggesting a disease-modifying effect of those treatments.
Details
| Lead sponsor | Hamilton Health Sciences Corporation |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 100 |
| Start date | 2007-02 |
| Completion | 2010-12 |
Conditions
- Alzheimer's Disease
Interventions
- doxycycline
- rifampicin
- Placebo matched to doxycycline
- Placebo matched to Rifampin
Primary outcomes
- Clinical Dementia Rating scale — 12 months
- Standardized Alzheimer's disease Assessment Scale -cognitive subscale — 12 months
Countries
Canada