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Effect of Ketamine (Ketalar) on Intracranial Pressure
Objectives: Ketamine is an effective, short-acting anesthetic drug, which does not decrease blood pressure. It is widely stated that Ketamine increases intracranial pressure (ICP), which prevents its use in many emergency situations, specifically in patients with traumatic brain injury (TBI) and with increased ICP. Based on previous clinical experience, we hypothesized that Ketamine decreases - rather than increases - ICP. Methods: Prospective, controlled, clinical trial. Children with ICP monitoring will receive a single Ketamine dose (1-1.5 mg/kg) either for increased ICP and/or before a potentially distressing activity. Hemodynamic variables, ICP and cerebral perfusion pressure (CPP) will be recorded 1 minute before and every minute for 10 minutes following Ketamine administration (Before/after design).
Details
| Lead sponsor | Rambam Health Care Campus |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 30 |
| Start date | 2005-09 |
| Completion | 2007-02 |
Conditions
- Traumatic Brain Injury
- Intracranial Hypertension
Interventions
- Ketamine, effect on intracranial pressure
Primary outcomes
- Effect on intracranial pressure
- Effect on hemodynamic variables
- Effect on cerebral perfusion pressure
Countries
Israel