Acute Effects of a Low-AGE vs. High-AGE Meal on Postprandial Endothelial Function in People With Type 2 Diabetes Mellitus. Protective Effects of Benfotiamine (AGE-Benfo)

NCT00437008 Phase 4 COMPLETED

The purpose of the study is to determine whether there are differences in postprandial endothelial function following a high-AGE(Advanced Glycation End-products) meal vs. a low-AGE meal. We also intend to investigate if the therapy with 1050mg Benfotiamine for 3 days protects against the postulated deterioration of endothelial function after a high-AGE meal in people with type 2 diabetes mellitus.

Details

Lead sponsor	Ruhr University of Bochum
Phase	Phase 4
Status	COMPLETED
Enrolment	21
Start date	2004-11
Completion	2006-01

Conditions

• Endothelial Dysfunction
• Type 2 Diabetes Mellitus

Interventions

• Benfotiamine 1050mg, 3 days
• high-AGE vs. low-AGE meal

Primary outcomes

• A high-AGE meal causes a more pronounced postprandial endothelial dysfunction comparing to a low-AGE meal in people with type 2 diabetes mellitus.

Countries

Germany