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NCT00434070
Relationship of Viral Resistance Development to CD4 Monitoring Alone or With Viral Load Monitoring
trial in Acquired Immunodeficiency Syndrome in 1,012 participants. Completed in 7 February 2013.
Quick facts
| Lead sponsor | National Institute of Allergy and Infectious Diseases (NIAID) |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 1,012 |
| Start date | 7 February 2007 |
| Estimated completion | 7 February 2013 |
| Sites | 1 location across Uganda |
Conditions studied
- Acquired Immunodeficiency Syndrome — all drugs for Acquired Immunodeficiency Syndrome →
- Resistance — all drugs for Resistance →
Sponsor
National Institute of Allergy and Infectious Diseases (NIAID)
Who can join
18 and older, any sex, with Acquired Immunodeficiency Syndrome or Resistance. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This study will examine whether HIV-infected patients are more likely to develop resistance to antiretroviral therapy if their blood is not monitored for the number of viruses (viral load) in the body. A virus that changes (mutates) over time may become resistant to certain types of medicine. This resistance may affect future treatment options. This study will compare the amount of virus in the blood of HIV-infected patients who have been monitored for viral load with the amount of virus in the blood of patients who have not been monitored for viral load. For patients who have detectable virus, the type of resistance (mutations) of the virus will be determined by comparing the components of the virus with that of a virus that is known not to be resistant. HIV-infected patients 18 years of age or older who are being treated at the Infectious Diseases Institute at Mulago Hospital at Makerere University in Kampala, Uganda, may be eligible for this study. Participants are interviewed about the treatments they have received for HIV and how they usually take their anti-HIV drugs. They also have a blood sample drawn for research tests.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Adult combination antiretroviral therapy in sub-Saharan Africa: lessons from Botswana and future challenges.
Wester CW, Bussmann H, Koethe J, Moffat C, et al · · 2009 · cited 15× · PMID 20161344 · DOI 10.2217/hiv.09.35
Verify or expand the search:
- PubMed search for NCT00434070
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Acquired Immunodeficiency Syndrome
Currently open trials in the same condition.
- NCT04983030 — Safety, Immunogenicity, Efficacy of Ad26.Mos4.HIV, MVA-BN-HIV and PGT121, PGDM1400, and VRC07-523LS in HIV-1-Infected Ad · Phase 1, PHASE2 · active not recruiting
- NCT02479698 — Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus · Phase 2 · recruiting
Other National Institute of Allergy and Infectious Diseases (NIAID) trials
Trials by the same sponsor.
- NCT07216794 — Small Trial of Alendronate Impact on the Reservoir of HIV · Phase 2 · not yet recruiting
- NCT07215858 — BPL-1357 Against H1N1 Influenza Virus Challenge · Phase 2 · recruiting
- NCT06987318 — A Study to Evaluate the Safety and Antiviral Activity of Two Human Monoclonal Antibodies (VRC07-523LS and PGT121.414.LS) · Phase 1 · not yet recruiting
- NCT07124559 — A Study of Daily Rifapentine Combined With Isoniazid (1HP) for Tuberculosis Prevention in Children Less Than 13 Years of · Phase 1, PHASE2 · not yet recruiting
- NCT07342491 — Dasatinib for HIV-1 Reservoir Reduction · Phase 1 · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00434070 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by National Institute of Allergy and Infectious Diseases (NIAID)
- Last refreshed: 12 December 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00434070.
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