Trial of Analgesia With Lidocaine or Extended-release Oxycodone for Neuropathic Pain Treatment in Multiple Sclerosis (TALENT-MS)

NCT00414453 Phase 4 TERMINATED Results posted

This study will determine whether treatment with an extended-release opioid or topical lidocaine is effective in relieving distal symmetric lower extremity burning pain associated with multiple sclerosis (MS). If treatment with topical lidocaine is efficacious, it will have important implications for understanding this chronic pain syndrome, which is widely assumed to be caused by central nervous system pathology.

Details

Lead sponsor	University of Rochester
Phase	Phase 4
Status	TERMINATED
Enrolment	19
Start date	2007-01
Completion	2011-08

Conditions

• Neuropathic Pain
• Chronic Pain
• Multiple Sclerosis

Interventions

• Lidocaine patch 5%
• Extended-release oxycodone
• Placebo extended-release oxycodone pills
• Placebo lidocaine patches

Primary outcomes

• Mean Daily Diary Pain Ratings During Final Week of Each Treatment Period — Daily
  subject identifies daily pain rating during final week of each treatment period using a numeric rating scale

Countries

United States