NCT00397748

PET Scanning of Adults With Attention Deficit Hyperactivity Disorder (ADHD)

Completed Last updated 16 December 2019

What this trial tests

trial in Volunteer in 16 participants. Completed in 27 November 2012.

Timeline

15 September 2006

27 November 2012

Quick facts

Lead sponsor	National Institute of Mental Health (NIMH)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	16
Start date	15 September 2006
Estimated completion	27 November 2012
Sites	1 location across United States

Conditions studied

• Volunteer — all drugs for Volunteer →
• Attention Deficit Hyperactivity Disorder — all drugs for Attention Deficit Hyperactivity Disorder →

Sponsor

National Institute of Mental Health (NIMH)

Who can join

Adults 18 to 55, male only, with Volunteer or Attention Deficit Hyperactivity Disorder. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will explore the brain in men with and without attention deficit hyperactivity disorder (ADHD). It will use positron emission tomography (PET) and magnetic resonance imaging (MRI) to study brain function and nerve cell communication involving phospholipids (fatty molecules that make up the covering of nerve cell fibers in the brain and are involved in communication between the cells). It will also look at how nerve cell communication is related to blood flow. In particular, the study will explore communication through the dopamine system, which is one of the main neurotransmitter systems in the brain involved in ADHD.

Healthy men and men with ADHD between 18 and 55 years of age may be eligible for this study.

Participants undergo the following procedures:

"\<TAB\>Medical history and psychiatric and medical evaluation, including blood and urine tests.

"\<TAB\>MRI scan. This test uses a strong magnetic field and radio waves to obtain images of the brain. The subject lies still on a table that slides into the scanner (a metal cylinder) during the scanning.

"\<TAB\>PET scanning. The subject lies on the scanner bed with his head held still using a special facemask. A catheter (plastic tube or needle) is placed in an artery to collect blood samples and in a vein to inject radioactive isotopes for measuring blood flow and phospholipid metabolism. Scans are done after an injection of a saline solution and again after injection of apomorphine, a medication that turns on dopamine receptors in the brain. The injections are given under the skin of the abdomen, about one and a half hours apart....

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.