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The Influence of High-Dose Aprotinin and Tranexamic Acid on Bleeding Tendency and Allogeneic Blood Transfusion in Patients Undergoing Primary Aortic Valve Replacement or Coronary Artery Revascularization
The hypothesis of this study is that the antifibrinolytic drugs aprotinin and tranexamic acid equally influence bleeding tendency and transfusion requirement in patients undergoing first time cardiac procedures with a low risk of increased postoperative bleeding.Only patients undergoing first time CABG or first time aortic valve replacement are included in this study.
Details
| Lead sponsor | German Heart Center |
|---|---|
| Phase | Phase 3 |
| Status | UNKNOWN |
| Enrolment | 220 |
| Start date | 2005-01 |
| Completion | 2006-07 |
Conditions
- Bleeding and Cardiac Surgery
- Allogeneic Blood Transfusion
- Aortic Valve Replacement
- Coronary Artery Bypass Graft Surgery
Interventions
- aprotinin or tranexamic acid
Primary outcomes
- 24 hours postoperative drainage blood loss
- incidence of allogeneic blood transfusion
Countries
Germany