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Treatment of Clozapine-Induced Hypersalivation Ipratropium Bromide
Hypersalivation (Too much saliva) and drooling is a side effect experienced by 31% of people taking the antipsychotic clozapine. This study aims to determine if using the medication ipratropium bromide(IPB)at bedtime will reduce the amount of salivation and the distress people may feel.
Details
| Lead sponsor | Centre for Addiction and Mental Health |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 25 |
| Start date | 2006-10 |
Conditions
- Hypersalivation
Interventions
- ipratropium bromide 0.03% spray
Primary outcomes
- Toronto Nocturnal Hypersalivation Scale scores — intermittent
- Visual Analogue Scale - Severity — intermittent
- Visual Analogue Scale - Distress — Intermittent
- Simpson-Angus Rating Scale — Each study visit
- Clinical Global Improvement Scale — Each study visit
Countries
Canada