NCT00374218 is a Phase 2 clinical trial of High Fructose Corn Syrup in Abdominal Obesity, sponsored by University of Toronto.

Who is sponsoring NCT00374218?

NCT00374218 is sponsored by University of Toronto.

What drugs are being tested in NCT00374218?

Interventions in NCT00374218: High Fructose Corn Syrup, Sucromalt.

What condition does NCT00374218 study?

NCT00374218 studies Abdominal Obesity.

Is NCT00374218 still recruiting?

NCT00374218 is currently completed. Last updated 13 August 2007.

Last reviewed 2007-08-13 · How we verify

NCT00374218

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effect of Replacing HFCS With Sucromalt on Glucose Tolerance, Blood Lipids and Inflammatory Markers in Subjects With Raised Waist Circumference

Completed Phase 2 Last updated 13 August 2007

What this trial tests

Phase 2 trial testing High Fructose Corn Syrup in Abdominal Obesity in 28 participants. Completed in 1 April 2007.

Timeline

1 September 2006

1 April 2007

Quick facts

Lead sponsor	University of Toronto
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	28
Start date	1 September 2006
Estimated completion	1 April 2007
Sites	1 location across Canada

Drugs / interventions tested

High Fructose Corn Syrup — full drug profile →
Sucromalt — full drug profile →

Conditions studied

Abdominal Obesity — all drugs for Abdominal Obesity →

Sponsor

University of Toronto

Who can join

Adults 20 to 50, any sex, with Abdominal Obesity. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Fasting and 2h glucose after 75g oral glucose tolerance test
Time frame: 4 weeks

Sponsor's own description

Weight gain is linked to a high consumption of soft-drinks and other beverages sweetened with high fructose corn syrup. Being overweight increases risk for diabetes and heart disease. These problems may be due to high blood glucose and insulin responses caused by high fructose corn syrup. Sucromalt is a sweetener which contains the same amount of carbohydrate at high fructose corn syrup, but causes lower glucose and insulin responses. The purpose of this study is to see if consuming soft-drinks and other foods sweetened with sucromalt instead of high fructose corn syrup will result in lower levels of blood glucose, insulin, cholesterol and other markers of risk. We are including in this study people who are overweight and normally consume soft-drinks because they are the ones most likely to benefit from this change.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

High versus low-added sugar consumption for the primary prevention of cardiovascular disease.
Bergwall S, Johansson A, Sonestedt E, Acosta S. · · 2022 · cited 10× · PMID 34986271 · DOI 10.1002/14651858.cd013320.pub2

Verify or expand the search:

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Other University of Toronto trials

Trials by the same sponsor.

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00374218 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University of Toronto
Last refreshed: 13 August 2007

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00374218.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing