Last reviewed · How we verify
The Effect of Glyceryl Trinitrate and Diamox on Blood-Oxygenation-Level-Dependent.Signal (BOLD-Signal) and Cerebral Haemodynamics With the Use of a 3-Tesla MRI-Scan.
In healthy subjects different cerebral haemodynamic values wished to be determined after infusion of the NO donor Glyceryl trinitrate (GTN) and Diamox. The different values we wish to determine are: * Blood-oxygenation-level-Dependent-signal (BOLD-signal) after visual stimulation. * Changes in the diameter of a. cerebri media. * Changes in the regional and global cerebral blodd flow (CBF) with the help of the arterial Spin labeling (ASL) method.
Details
| Lead sponsor | Danish Headache Center |
|---|---|
| Phase | NA |
| Status | UNKNOWN |
| Enrolment | 12 |
| Completion | 2007-05 |
Conditions
- Healthy
Interventions
- Glyceryl trinitrate, azetazolamide
Primary outcomes
- Changes in BOLD response
- Changes in a. cerebri media diameter
- Changes in CBF
Countries
Denmark