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A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia (AspECT)
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of esomeprazole and aspirin may prevent esophageal cancer in patients with Barrett's metaplasia. It is not yet known whether esomeprazole is more effective with or without aspirin in preventing esophageal cancer in patients with Barrett's metaplasia. PURPOSE: This randomized phase III trial is studying esomeprazole with or without aspirin to compare how well they work in preventing esophageal cancer in patients with Barrett's metaplasia.
Details
| Lead sponsor | University of Oxford |
|---|---|
| Phase | PHASE3 |
| Status | COMPLETED |
| Enrolment | 2557 |
| Start date | Thu Mar 10 2005 00:00:00 GMT+0000 (Coordinated Universal Time) |
| Completion | Wed May 31 2017 00:00:00 GMT+0000 (Coordinated Universal Time) |
Conditions
- Esophageal Cancer
- Precancerous Condition
Interventions
- Esomeprazole
- Esomeprazole
- Aspirin