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Randomized Trial of Sulfadoxine-Pyrimethamine Plus Artesunate (SP+AS) Versus SP+AS Plus Primaquine for Clearance of Low Density P. Falciparum Infection in Eastern Sudan
In areas of seasonal malaria transmission, treatment of carriers of malaria parasites, whose parasitaemia persists at very low levels throughout the dry season, could be a useful strategy for malaria control in areas with a short transmission season. We did a randomized trial to compare two regimens for clearance of low level parasitaemia in the dry season.
Details
| Lead sponsor | London School of Hygiene and Tropical Medicine |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 104 |
| Start date | 2004-01 |
| Completion | 2004-11 |
Conditions
- Plasmodium Infections
Interventions
- sulfadoxine-pyrimethamine (SP) plus artesunate (AS)
- primaquine (PQ) plus SP+AS
Primary outcomes
- P.falciparum parasitaemia detected by PCR on days 3,7 and 14. — 14 days from start of treatment
Countries
Sudan