Eliminating Trachoma With Repeat Mass Drug Treatment (TANA)

NCT00322972 Phase 4 COMPLETED

The WHO has initiated a program to eliminate trachoma, blinding eye infection caused by Chlamydia trachomatis, in large part by mass distributions of oral azithromycin. The proposed study will determine the frequency and treatment target of community-wide mass antibiotic treatment. We will also study the impact of mass antibiotic distribution on antibiotic-resistance in pneumococcus.

Details

Lead sponsor	University of California, San Francisco
Phase	Phase 4
Status	COMPLETED
Enrolment	33000
Start date	2006-06
Completion	2014-05

Conditions

• Trachoma
• Chlamydia

Interventions

• Mass treatment with oral azithromycin to an entire community

Primary outcomes

• The average prevalence of ocular chlamydia infection in communities in an arm as determined by pooled NAAT (Nucleic Acid Amplification Test)(at 42 months for Aim 1, at 12 months for Aim 2, post-treatment relative to pre-treatment for Aim 3) — 42 months

Countries

Ethiopia