A Trial of the Effects of Bupropion, Nicotine Replacement Therapy and CBT on Smoking Cessation and Smoking Relapse in Patients With Schizophrenia

NCT00320697 Phase 4 COMPLETED

This study seeks to determine if continued treatment with bupropion and nicotine replacement therapy (NRT) can reduce the smoking relapse rate in patients with schizophrenia.

Details

Lead sponsor	North Suffolk Mental Health Association
Phase	Phase 4
Status	COMPLETED
Enrolment	25
Start date	2006-04
Completion	2009-08

Conditions

• Schizophrenia
• Schizoaffective Disorder
• Smokers

Interventions

• bupropion + nicotine patch + nicotine gum or lozenges
• Placebo pill + placebo patch

Primary outcomes

• Effectiveness of 44 weeks extended duration combination treatment with bupropion SR and NRT compared with placebo on 7-day point-prevalence abstinence at the end of the 44-week of the randomized phase — 7-day point-prevalence abstinence at the end of the 44-week of the randomized phase

Countries

United States