Double-blind, Crossover, Placebo-controlled Evaluation of the Effect of Levalbuterol (R-albuterol) on Allergen Induced Airway Inflammation In Subjects With Atopic Asthma

NCT00320034 Phase 2 COMPLETED

The most commonly used drug for immediate relief of symptoms of asthma is the blue puffer, albuterol or salbutamol (Ventolin). Racemic albuterol is a mixture of two forms of albuterol which are mirror images of each other i.e. R-and S- isomers. The investigational treatments are R-albuterol and S-albuterol. R-albuterol ( levalbuterol) has been shown to have a slightly better bronchodilator effect as compared to the racemic albuterol and is well- tolerated in patients. However it is still not clear whether the S-isomer has no effect or has a harmful effect on the airways. The purpose of this study is to compare the effects of the R- and S- isomers on allergen induced airway inflammation in subjects with mild atopic asthma. This will give us a better idea as to whether the routine use of levalbuterol is superior to racemic albuterol.

Details

Lead sponsor	Hamilton Health Sciences Corporation
Phase	Phase 2
Status	COMPLETED
Enrolment	15
Start date	2006-04
Completion	2009-11

Conditions

• Asthma

Interventions

• R-albuterol, S-albuterol

Primary outcomes

• The change in airway eosinophil number (% and absolute numbers) following an allergen inhalation.