NCT00318708 (MIA) is a Phase 3 clinical trial of clarithromycin in Asthma, sponsored by Milton S. Hershey Medical Center.

Who is sponsoring NCT00318708?

NCT00318708 is sponsored by Milton S. Hershey Medical Center.

What drugs are being tested in NCT00318708?

Interventions in NCT00318708: clarithromycin, fluticasone propionate, placebo clarithromycin.

Is NCT00318708 still recruiting?

NCT00318708 is currently completed. Last updated 22 March 2018.

Are results published for NCT00318708?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2018-03-22 · How we verify

NCT00318708: MIA

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Asthma Clinical Research Network (ACRN) Trial - Macrolides in Asthma (MIA)

Completed Phase 3 Results posted Last updated 22 March 2018

What this trial tests

Phase 3 trial testing clarithromycin in Asthma in 92 participants. Completed in 1 April 2009.

Timeline

1 June 2006

Primary endpoint
1 April 2009

1 April 2009

Quick facts

Lead sponsor	Milton S. Hershey Medical Center
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	92
Start date	1 June 2006
Primary completion	1 April 2009
Estimated completion	1 April 2009
Sites	10 locations across United States

Drugs / interventions tested

clarithromycin (clarithromycin) — full drug profile →
fluticasone propionate (FLUTICASONE PROPIONATE) — full drug profile →
placebo clarithromycin

Conditions studied

Asthma — all drugs for Asthma →

Sponsor

Milton S. Hershey Medical Center

Who can join

Adults 18 to 60, any sex, with Asthma. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Juniper Asthma Control Questionnaire (ACQ) Results
Time frame: Measured every four weeks during the 16-week treatment period, with the change (week 16 minus baseline) as the primary outcome
The Juniper asthma control questionnaire (ACQ) consists of six questions answered by the asthma patient with respect to symptoms, rescue medication use, and night-time awakenings due to asthma. A seventh item in the ACQ is the percent predicted FEV1. Each of the seven items is scored from from 0 (best) to 6 (worst), and then the seven items are averaged to yield a number from 0 (best) to 6 (worst)

Sponsor's own description

Asthma can be caused by a variety of factors, including tobacco smoke, allergens, and respiratory airway infections. Many people use inhaled corticosteroid medications to treat their symptoms. These medications, however, are not effective for everyone. Clarithromycin is an antibiotic that may effectively treat asthma in these individuals. This study will evaluate the effectiveness of clarithromycin at controlling asthma symptoms.

Publications & conference data

5 peer-reviewed publications reference this trial (live from Europe PMC):

Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma.
Huang YJ, Nelson CE, Brodie EL, Desantis TZ, et al · · 2011 · cited 539× · PMID 21194740 · DOI 10.1016/j.jaci.2010.10.048
A trial of clarithromycin for the treatment of suboptimally controlled asthma.
Sutherland ER, King TS, Icitovic N, Ameredes BT, et al · · 2010 · cited 100× · PMID 20920764 · DOI 10.1016/j.jaci.2010.07.024
Macrolides versus placebo for chronic asthma.
Undela K, Goldsmith L, Kew KM, Ferrara G. · · 2021 · cited 15× · PMID 34807989 · DOI 10.1002/14651858.cd002997.pub5
Delivering macrolide antibiotics to heal a broken heart - And other inflammatory conditions.
Venditto VJ, Feola DJ. · · 2022 · cited 10× · PMID 35367307 · DOI 10.1016/j.addr.2022.114252
Standardized method to minimize variability in a functional P2X(7) flow cytometric assay for a multi-center clinical trial.
Korpi-Steiner NL, Sheerar D, Puffer EB, Urben C, et al · · 2008 · cited 8× · PMID 18431793 · DOI 10.1002/cyto.b.20421

Verify or expand the search:

Other trials of clarithromycin

Trials testing the same drug.

NCT06964334 — The Effect of Vitamin D Supplement as Adjuvant Therapy in Eradication of Helicobacter Pylori Infection · Phase 3 · not yet recruiting
NCT06837259 — A Study to Learn if Study Medicines Called Cyclosporine and Clarithromycin Affect How the Body Processes the Other Study · Phase 1 · completed
NCT06523764 — Efficacy and Safety of Tegoprazan and Minocycline Dual Therapy for Helicobacter Pylori Initial Treatment · Phase 4 · active not recruiting
NCT06603688 — Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the · Phase 4 · unknown
NCT05237115 — Helicobacter Pylori Eradication With Probiotics Combined With Triple Therapy Versus Bismuth-containing Quadruple Therapy · Phase 4 · completed

Other recruiting trials for Asthma

Currently open trials in the same condition.

NCT07525375 — A Phase II Study to Investigate Lung Function With 2 Different Doses of Inhaled Glycopyrronium Taken With BFF Compared t · Phase 2 · recruiting
NCT07536256 — Community Connections Through Native Hawaiian Cultural Values to Strengthen Youth Resilience, Health, and Well-Being · NA · recruiting
NCT07556159 — A Study Evaluating Disease Characteristics and Outcomes in Participants With Asthma in Routine Clinical Practice · recruiting
NCT07282886 — VENTURI (VENTilation Using Respiratory Imaging) · Phase 2 · recruiting
NCT07433569 — A Study to Investigate How Budesonide and Formoterol Move Through the Body (Pharmacokinetics) When Delivered With Differ · Phase 1 · recruiting

Other Milton S. Hershey Medical Center trials

Trials by the same sponsor.

NCT05180552 — The HEALiX: Comparing the Efficacy of the HEALiX Device With Wrist Restraints in a Critical Care Setting · NA · withdrawn
NCT07461844 — Transdiagnostic Sleep and Circadian Treatment for Autistic Adults · NA · not yet recruiting
NCT06253858 — Ultrasound (US) Guided External Ventricular Catheter Placement · NA · not yet recruiting
NCT07225699 — IN PATIENTS WITH CORNEAL ABRASIONS TREATED WITH COLLAGEN CORNEAL SHIELDS IN THE EMERGENCY DEPARTMENT SETTING · NA · not yet recruiting
NCT07461168 — Penn State Emergency Medicine CarES: Care-partner Evaluation and Sourcing in the Emergency Department · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00318708 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Milton S. Hershey Medical Center
Last refreshed: 22 March 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00318708.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing