Who is sponsoring NCT00313378?

NCT00313378 is sponsored by University Hospital, Clermont-Ferrand.

What drugs are being tested in NCT00313378?

Interventions in NCT00313378: Hypothetica.

Is NCT00313378 still recruiting?

NCT00313378 is currently completed. Last updated 2 April 2013.

Last reviewed 2013-04-02 · How we verify

NCT00313378

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Perioperative Systemic Ketamine on Development of Long-term Neuropathic Pain After Thoracotomy.

Completed Phase 3 Last updated 2 April 2013

What this trial tests

Phase 3 trial testing Hypothetica in Partial Pneumonectomy Under Lateral or Posterolateral Thoracotomy. in 78 participants. Completed in 1 May 2008.

Timeline

1 April 2004

Primary endpoint
1 May 2008

1 May 2008

Quick facts

Lead sponsor	University Hospital, Clermont-Ferrand
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	78
Start date	1 April 2004
Primary completion	1 May 2008
Estimated completion	1 May 2008
Sites	1 location across France

Drugs / interventions tested

Hypothetica — full drug profile →

Conditions studied

Partial Pneumonectomy Under Lateral or Posterolateral Thoracotomy. — all drugs for Partial Pneumonectomy Under Lateral or Posterolateral Thoracotomy. →

Sponsor

University Hospital, Clermont-Ferrand

Who can join

Adults 20 to 75, any sex, with Partial Pneumonectomy Under Lateral or Posterolateral Thoracotomy.. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Reduction of chronic pain

Sponsor's own description

Lung surgery under thoracotomy is known to induce long-term pain which can be considered as neuropathic in many patients concerned \[1,2\]. The suspected origin of neuropathy is a direct traumatism of intercostal nerve(s) \[3\]. Among the possible preventive treatments that can be administered during the initial aggression, ketamine \[4,5\] appears as the easiest to use, as it is already commonly administered intra and postoperatively for improvement of analgesia \[6\].

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

The neuropathic pain: An overview of the current treatment and future therapeutic approaches.
Cavalli E, Mammana S, Nicoletti F, Bramanti P, et al · · 2019 · cited 353× · PMID 30900486 · DOI 10.1177/2058738419838383
NMDA receptors in clinical neurology: excitatory times ahead.
Kalia LV, Kalia SK, Salter MW. · · 2008 · cited 307× · PMID 18635022 · DOI 10.1016/s1474-4422(08)70165-0

Verify or expand the search:

Other University Hospital, Clermont-Ferrand trials

Trials by the same sponsor.

NCT07179276 — Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock · NA · recruiting
NCT07476768 — PAINDYS_Characterizing Pain in Fibrous Dysplasia of Bone/McCune-Albright Syndrome: an Exploratory Pilot Study · NA · not yet recruiting
NCT07439146 — Risk of Pneumonia in Intubated Patients in Emergency Situations · not yet recruiting
NCT07427537 — Exploration of Circulating microRNAs as Biomarkers of Chemo-induced Peripheral Neuropathy: a Study in Cancer Patients · NA · recruiting
NCT07330856 — Evaluation of Treatments for Dry or Productive Cough · Phase 4 · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00313378 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by University Hospital, Clermont-Ferrand
Last refreshed: 2 April 2013

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00313378.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing