A Randomized Phase III Study Comparing Cyclophosphamide + Methotrexate + Fluorouracil vs. Goserelin + Tamoxifen in Premenopausal, Hormone Receptor-positive, Lymph Node-positive or -Negative Patients

NCT00309478 Phase 3 COMPLETED

Primarily, this clinical investigation compared the efficacy of cyclophosphamide + methotrexate + fluorouracil chemotherapy vs. goserelin + tamoxifen treatment in terms of prognosis (disease-free survival, overall survival) in premenopausal patients with potentially curative, operated hormone receptor-positive breast cancer.

Details

Lead sponsor	Austrian Breast & Colorectal Cancer Study Group
Phase	Phase 3
Status	COMPLETED
Enrolment	1099
Start date	1990-12
Completion	2004-06

Conditions

• Early-stage Breast Cancer

Interventions

• Cyclophosphamide
• Methotrexate
• Fluorouracil implant
• Goserelin
• Tamoxifen

Primary outcomes

• Disease-free survival
• Overall survival