NCT00306748 is a Phase 2 clinical trial of MD-1100 Acetate in Constipation, sponsored by Ironwood Pharmaceuticals, Inc..

Who is sponsoring NCT00306748?

NCT00306748 is sponsored by Ironwood Pharmaceuticals, Inc..

What drugs are being tested in NCT00306748?

Interventions in NCT00306748: MD-1100 Acetate.

What condition does NCT00306748 study?

NCT00306748 studies Constipation.

Is NCT00306748 still recruiting?

NCT00306748 is currently completed. Last updated 22 March 2009.

Last reviewed 2009-03-22 · How we verify

NCT00306748

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Randomized, Multicenter, Double-Blind, Parallel-Design, Phase 2 Trial of Oral MD-1100 Acetate Administered for 14 Days Once Daily at 100 ug, 300 ug, 1000 ug, or Placebo to Patients With Chronic Constipation

Completed Phase 2 Last updated 22 March 2009

What this trial tests

Phase 2 trial testing MD-1100 Acetate in Constipation in 40 participants. Completed in 1 August 2006.

Timeline

1 March 2006

1 August 2006

Quick facts

Lead sponsor	Ironwood Pharmaceuticals, Inc.
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	40
Start date	1 March 2006
Estimated completion	1 August 2006
Sites	14 locations across United States

Drugs / interventions tested

MD-1100 Acetate — full drug profile →

Conditions studied

Constipation — all drugs for Constipation →

Sponsor

Ironwood Pharmaceuticals, Inc. — full company profile →

Who can join

Adults 18 to 70, any sex, with Constipation. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Safety will be evaluated on an ongoing basis by completing physical examinations, ECGs, clinical laboratory tests, and adverse event reporting.

Sponsor's own description

The purpose of this study is to determine the safety and gastrointestinal pharmacodynamics (stool frequency, stool consistency, stool ease of passage, stool completeness of evacuation) of MD-1100 acetate administered daily for 14 days.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

Other recruiting trials for Constipation

Currently open trials in the same condition.

NCT07462481 — Probiotic Improve Constipation · NA · recruiting
NCT07466914 — Constipation in Children With Cerebral Palsy · active not recruiting
NCT07215351 — Impact of the Inno Cleanse Dietary Supplement on Gut Health and Associated Variables in Healthy Men and Women · NA · recruiting
NCT07135362 — The Efficacy Evaluation of TCI604 Probiotic on Intestinal Function Improvement · NA · recruiting
NCT07091084 — A Study of Herbal Supplements in Cancer Survivors With Constipation · NA · recruiting

Other Ironwood Pharmaceuticals, Inc. trials

Trials by the same sponsor.

NCT05740007 — A Phase 2 Study of IW-3300 for the Treatment of Bladder Pain in Subjects With Interstitial Cystitis/Bladder Pain Syndrom · Phase 2 · terminated
NCT05362695 — A Study of Multiple-ascending Doses of IW-3300 in Healthy Subjects · Phase 1 · completed
NCT05188261 — A Study of Single Ascending Doses of IW-3300 in Healthy Volunteers · Phase 1 · completed
NCT03931785 — A Study of MD-7246 to Treat Abdominal Pain in Patients With Diarrhea-predominant Irritable Bowel Syndrome · Phase 2 · completed
NCT03856970 — Study to Evaluate the Effect of IW-3718 on the Pharmacokinetics of Oral Contraceptive, Levothyroxine, Glyburide, and Dig · Phase 1 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00306748 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Ironwood Pharmaceuticals, Inc.
Last refreshed: 22 March 2009

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00306748.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing