Effects of Doxazosin on Ambulatory Blood Pressure and Sympathetic Nervous Activity in Hypertensive Patients With Diabetic Nephropathy

NCT00295555 Phase 4 COMPLETED

Few studies have reported the effect of alpha1-adrenergic antagonists on 24-h blood pressure and regulation of sympathetic nervous activity in hypertensive patients with diabetic nephropathy. Using ambulatory blood pressure monitoring devices equipped with spectral analysis of heart rate variability, we assess the effects of doxazosin on blood pressure in diabetic nephropathy patients and compare the results with those in patients with essential hypertension, patients with diabetes mellitus and patients with chronic nephropathy.

Details

Lead sponsor	Yokohama City University Medical Center
Phase	Phase 4
Status	COMPLETED
Enrolment	98
Start date	2004-01
Completion	2007-04

Conditions

• Diabetes Mellitus
• Essential Hypertension
• Renal Failure

Interventions

• Effects of doxazosin on morning surge in diabetic patients

Primary outcomes

• Normalization of high blood pressure — One year

Countries

Japan