Prognostic Value of Ambulatory Blood Pressure Monitoring in the Prediction of Cardiovascular Events and Effects of Chronotherapy in Relation to Risk (the MAPEC Study).

NCT00295542 Phase 4 COMPLETED

The MAPEC study was designed to investigate whether normalizing the circadian blood pressure profile towards a more dipper pattern (increasing the diurnal/nocturnal ratio of blood pressure) by the use of Chronotherapy (that is, taking into account the time of day of administration of antihypertensive medications) reduces cardiovascular risk.

Details

Lead sponsor	University of Vigo
Phase	Phase 4
Status	COMPLETED
Enrolment	3344
Start date	2000-03
Completion	2009-04

Conditions

• Hypertension

Interventions

• Ambulatory blood pressure monitoring
• Chronotherapy, timing of antihypertensive medication
• ACEI (including spirapril, enalapril, quinapril, lisinopril)
• ARB (including valsartan, telmisartan, olmesartan)
• beta blockers (including nebivolol, atenolol, carvedilol)
• diuretics (torasemide, indapamide, HTCZ) and doxazosin
• Combination therapy in essential hypertension

Primary outcomes

• Prognostic value of ABPM, impact of changes in ambulatory BP and impact of circadian time of antihypertensive treatment in cardiovascular, cerebrovascular and renal risk assessment. — Five years

Countries

Spain