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NCT00279318

TEDDY - The Environmental Determinants of Diabetes in the Young

Completed Last updated 22 September 2025
What this trial tests

trial in Type 1 Diabetes Mellitus in 8,667 participants. Completed in 30 June 2025.

Timeline
1 September 2004
Primary endpoint
30 June 2025
30 June 2025

Quick facts

Lead sponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
StatusCompleted
Study typeOBSERVATIONAL
Enrollment8,667
Start date1 September 2004
Primary completion30 June 2025
Estimated completion30 June 2025
Sites7 locations across Sweden, Finland, United States, Germany

Conditions studied

Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who can join

Adults 0 Months to 4 Months, any sex, with Type 1 Diabetes Mellitus. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The long-term goal of the TEDDY study is the identification of infectious agents, dietary factors, or other environmental agents, including psychosocial factors which trigger T1DM in genetically susceptible individuals or which protect against the disease. Identification of such factors will lead to a better understanding of disease pathogenesis and result in new strategies to prevent, delay or reverse T1DM.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

  1. The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants.
    Hagopian WA, Erlich H, Lernmark A, Rewers M, et al · · 2011 · cited 194× · PMID 21564455 · DOI 10.1111/j.1399-5448.2011.00774.x
  2. The relationship between breastfeeding and reported respiratory and gastrointestinal infection rates in young children.
    Frank NM, Lynch KF, Uusitalo U, Yang J, et al · · 2019 · cited 129× · PMID 31533753 · DOI 10.1186/s12887-019-1693-2
  3. A combined risk score enhances prediction of type 1 diabetes among susceptible children.
    Ferrat LA, Vehik K, Sharp SA, Lernmark Å, et al · · 2020 · cited 121× · PMID 32770166 · DOI 10.1038/s41591-020-0930-4
  4. Predictors of the Initiation of Islet Autoimmunity and Progression to Multiple Autoantibodies and Clinical Diabetes: The TEDDY Study.
    Krischer JP, Liu X, Lernmark Å, Hagopian WA, et al · · 2022 · cited 66× · PMID 36150053 · DOI 10.2337/dc21-2612
  5. An Age-Related Exponential Decline in the Risk of Multiple Islet Autoantibody Seroconversion During Childhood.
    Bonifacio E, Weiß A, Winkler C, Hippich M, et al · · 2021 · cited 45× · PMID 33627366 · DOI 10.2337/dc20-2122
  6. Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study.
    Auchtung TA, Stewart CJ, Smith DP, Triplett EW, et al · · 2022 · cited 35× · PMID 35672407 · DOI 10.1038/s41467-022-30686-w
  7. Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample.
    Bediaga NG, Li-Wai-Suen CSN, Haller MJ, Gitelman SE, et al · · 2021 · cited 30× · PMID 34338806 · DOI 10.1007/s00125-021-05523-2
  8. Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families.
    Hippich M, Beyerlein A, Hagopian WA, Krischer JP, et al · · 2019 · cited 27× · PMID 30655385 · DOI 10.2337/db18-0882

Verify or expand the search:

Other recruiting trials for Type 1 Diabetes Mellitus

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Data sources for this page

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