A Randomized Study to Compare the Acne Relapse Rate After a 3-mo Course of Oral Minocycline, to a 3-mo Course of Oral Minocycline in Combination With a Daily Dose of Topical Tretinoin 0.01% Followed by 3 mo of Topical Tretinoin Alone

NCT00240513 Phase 4 TERMINATED

The use of oral antibiotics alone to treat inflammatory acne provides little to no long term therapeutic benefit. Acne relapse rates can be reduced by using topical tretinoin 0.01% in conjunction with minocycline, thereby increasing the therapeutic effect of the oral antibiotic.

Details

Lead sponsor	Derm Research @ 888 Inc.
Phase	Phase 4
Status	TERMINATED
Enrolment	38
Start date	2004-08
Completion	2006-12

Conditions

• Acne Vulgaris

Interventions

• Minocycline
• Minocycline plus tretinoin

Primary outcomes

• Long-term efficacy — 4 years

Countries

Canada