Medical Research Council Working Party on Leukaemia in Children UK National Acute Lymphoblastic Leukaemia (ALL) Trial: UKALL 2003

NCT00222612 Phase 4 UNKNOWN

A randomised trial for children with acute lymphoblastic leukemia, using the detection of minimal residual disease to define risk groups, aiming to answer the questions: 1. Can treatment be reduced without compromising efficacy in a MRD-defined low risk group? 2. Does further post-remission intensification improve outcome for a MRD-defined high risk group? 3. Measure the Quality of Life impact of the different treatment arms on the children and their families.

Details

Lead sponsor	University of Oxford
Phase	Phase 4
Status	UNKNOWN
Enrolment	2100
Start date	2003-10
Completion	2013-08

Conditions

• Acute Lymphoblastic Leukemia

Interventions

• Reduced intensification
• Standard childhood UK ALL protocol
• Intensified treatment including Capizzi maintenance

Primary outcomes

• Event free survival — 5 years

Countries

United Kingdom