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NCT00219856
Prospective, Randomized, Simple Blind Study Comparing the Effects of an Anaesthesia With Propofol to an Anaesthesia With Desflurane on Oxydative Stress and Liver Function Recovery After Hepatectomy
Phase 3 trial testing Propofol in Hepatectomy in 34 participants. Completed in 1 March 2006.
1 March 2006
Quick facts
| Lead sponsor | Rennes University Hospital |
|---|---|
| Phase | Phase 3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | treatment |
| Enrollment | 34 |
| Start date | 1 August 2004 |
| Primary completion | 1 March 2006 |
| Estimated completion | 1 March 2006 |
| Sites | 1 location across France |
Drugs / interventions tested
- Propofol (Propofol) — full drug profile →
- Penthotal — full drug profile →
- Desflurane (DESFLURANE) — full drug profile →
Conditions studied
- Hepatectomy — all drugs for Hepatectomy →
Sponsor
Rennes University Hospital
Who can join
18 and older, any sex, with Hepatectomy. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Plasma MDA levels
Time frame: 30 minutes after the end of hepatic clamping
Sponsor's own description
Propofol is an anaesthetic agent that showed in vitro and in vivo anti oxidant properties. No data are available concerning the potential benefit of a total anaesthesia with propofol in partial hepatic surgery. Patients who undergo partial hepatic resection have frequent liver insufficiency that could be related in part to the oxidative stress induced by clamping the hepatic vessels during the surgical intervention. Our hypothesis is that propofol, by increasing liver resistance to this ischemia-reperfusion phenomenon, could improve the remaining liver function recovery, and therefore could reduce post surgical morbidity. The aim of the study is to evaluate the anti oxidant effects of propofol compared to another widely used anaesthetic agent, inhaled desflurane, during and after partial hepatic resection with hepatic vessels clamping. The primary endpoint will be the level of malondialdehyde (a plasmatic marker of oxidative stress), 30 minutes after the end of hepatic clamping.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
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Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.
Ma X, Huang T, Chen X, Li Q, et al · · 2025 · cited 44× · PMID 39920130 · DOI 10.1038/s41392-024-02104-8
Verify or expand the search:
- PubMed search for NCT00219856
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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- NCT07347496 — A Randomized, Controlled Clinical Trial Comparing Remimazolam Besylate Combined With Alfentanil Versus Propofol Combined · Phase 4 · not yet recruiting
Other recruiting trials for Hepatectomy
Currently open trials in the same condition.
- NCT07507643 — A Study of Methylprednisolone in People Having Liver Surgery · Phase 3 · recruiting
- NCT07062380 — AI-Based Prediction of HCC Recurrence Patterns After Resection (APAR) · recruiting
- NCT06950827 — Textbook Outcomes of Right Hemihepatectomy in Patients With Hepatocellular Carcinoma · recruiting
- NCT07385521 — The Use of Artificial Intelligence for the Prediction of Recurrence After Resection of Colorectal Liver Metastases · recruiting
- NCT06237751 — Preoperative Sildenafil Administration for Hepatectomy · NA · recruiting
Other Rennes University Hospital trials
Trials by the same sponsor.
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- NCT07449832 — Sperm Epigenome in Hodgkin Lymphoma · NA · not yet recruiting
- NCT06950398 — Normothermic Oxygenated Perfusion (NMP) Viability Testing Before Transplantation of Discarded Livers · Phase 2 · not yet recruiting
- NCT07188753 — Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-b · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT00219856 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rennes University Hospital
- Last refreshed: 25 June 2012
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00219856.
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