NCT00199043 is a Phase 3 clinical trial of Allopurinol in Adult Acute Lymphocytic Leukemia, sponsored by Goethe University.

Who is sponsoring NCT00199043?

NCT00199043 is sponsored by Goethe University.

What drugs are being tested in NCT00199043?

Interventions in NCT00199043: Allopurinol, Rasburicase.

What condition does NCT00199043 study?

NCT00199043 studies Adult Acute Lymphocytic Leukemia, High-grade Lymphoma.

Is NCT00199043 still recruiting?

NCT00199043 is currently completed. Last updated 15 March 2023.

Last reviewed 2023-03-15 · How we verify

NCT00199043

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Randomised Phase III Trial of Effectivity and Safety of Rasburicase Compared With Allopurinol for Treatment of Hyperuricemia in Patients With Acute Lymphoblastic Leukemia or High-Grade NHL With High Risk of Tumorlysis Syndrome (> 15 Yrs)

Completed Phase 3 Last updated 15 March 2023

What this trial tests

Phase 3 trial testing Allopurinol in Adult Acute Lymphocytic Leukemia in 80 participants. Completed in 1 May 2008.

Timeline

1 May 2003

Primary endpoint
1 May 2008

1 May 2008

Quick facts

Lead sponsor	Goethe University
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	80
Start date	1 May 2003
Primary completion	1 May 2008
Estimated completion	1 May 2008
Sites	1 location across Germany

Drugs / interventions tested

Allopurinol (ALLOPURINOL) — full drug profile →
Rasburicase — full drug profile →

Conditions studied

Adult Acute Lymphocytic Leukemia — all drugs for Adult Acute Lymphocytic Leukemia →
High-grade Lymphoma — all drugs for High-grade Lymphoma →

Sponsor

Goethe University

Who can join

15 and older, any sex, with Adult Acute Lymphocytic Leukemia or High-grade Lymphoma. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

renal function, uric acid, electrolytes, adverse events and mortality in pre-phase and the two following cycles of chemotherapy, time and dose compliance of chemotherapy
Time frame: 3 weeks
after cycle 1

Sponsor's own description

In this study the efficacy and tolerability of two approaches to treat and prevent hyperuricemia is tested in patients with acute lymphoblastic leukemia or high-grade lymphoma with high risk of tumor lysis syndrome. Both arms are compared by randomisation. In one arm patients receive during pre-phase chemotherapy conventional prophylaxis with allopurinol whereas in the other arm Rasburicase is used.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer.
Cheuk DK, Chiang AK, Chan GC, Ha SY. · · 2017 · cited 12× · PMID 28272834 · DOI 10.1002/14651858.cd006945.pub4

Verify or expand the search:

Other trials of Allopurinol

Trials testing the same drug.

NCT07089888 — A Study of Dotinurad Versus Allopurinol in Tophaceous Gout · Phase 3 · recruiting
NCT07089875 — A Study of Dotinurad Versus Allopurinol in Participants With Gout · Phase 3 · recruiting
NCT05888233 — Allopurinol Improves Heart Function in African Americans With Resistant Hypertension · Phase 2 · recruiting
NCT06276556 — Extension Study of ABP-671 in Participants With Gout · Phase 2, PHASE3 · terminated
NCT04875702 — Treat-to-Target Serum Urate Versus Treat-to-Avoid Symptoms in Gout · Phase 4 · recruiting

Other Goethe University trials

Trials by the same sponsor.

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NCT06879184 — Cohort of the Specialist Network Infectious Diseases · not yet recruiting
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NCT06627140 — Expected and Actual Preterm-Birth and Parental Distress: Impact on Children's Mental Health · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00199043 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Goethe University
Last refreshed: 15 March 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00199043.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing