NCT00179322

Effects of Sleep Deprivation and Recovery on Cognitive Functions

Completed Last updated 17 December 2019

What this trial tests

trial in Sleep Deprivation in 29 participants. Completed in 30 September 2016.

Timeline

10 September 2005

30 September 2016

Quick facts

Lead sponsor	National Institute on Deafness and Other Communication Disorders (NIDCD)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	29
Start date	10 September 2005
Estimated completion	30 September 2016
Sites	1 location across United States

Conditions studied

• Sleep Deprivation — all drugs for Sleep Deprivation →

Sponsor

National Institute on Deafness and Other Communication Disorders (NIDCD)

Who can join

Adults 20 to 40, any sex, with Sleep Deprivation. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will measure brain activity in individuals performing language tasks while in various states of alertness to learn more about how the central nervous system is affected by impairments such as sleepiness.

Healthy normal volunteers between 20 and 40 years of age may be eligible for this study. Candidates must be non-smokers, right-handed, speak English fluently and have at least 12 years of education. They are screened with a medical history, physical examination, hearing and speech evaluation, computer task training, blood and urine tests and a late-night functional magnetic resonance imaging (fMRI) scan (see description below). Before screening and again before participating in the study, candidates wear an actigraph (a wristwatch-like device that records motion) for 7 days to provide a measure of their sleep-wake patterns.

Participants undergo the following tests and procedures:

* Extended wakefulness: Subjects are kept awake longer than is normal for them in their everyday life to be able to examine the brain under conditions of sleepiness. They are engaged in activities with the research staff during this waking time.
* Functional magnetic resonance imaging: Subjects undergo five separate fMRI scans-one during screening and four others during the main part of the study. fMRI uses a magnetic field and radio waves to produce images of the brain. The subject lies on a table that is moved into the scanner (a narrow cylinder), wearing earplugs to muffle loud knocking and thumping sounds that occur during the scanning process. Brain scans are taken at rest and while the subject performs tasks, which include pressing a button upon seeing certain shapes and performing various language tasks, such as saying memorized or new words, listening to narratives, and describing everyday procedures.
* Neurological, speech-language, and neuropsychological testing: Before the fMRI exams and during the period of extended wakefulness, subjects complete a series of tests that measure speech, language, memory and visual skills. Portions of the tests may be video- or autiotaped.
* Interviews and questionnaires: Participants are interviewed about their handedness, sleep history, and presence of medical or neurological symptoms.
* Electrophysiological studies: Subjects have an electroencephalograph (EEG) to measure the electrical activity of the brain and surface electromyography (EMG) to measure movements of muscles involved in moving and speaking. For the EEG, electrodes (small metal disks) are attached to the surface of the scalp or to a cap placed over the head. For the EMG, electrodes are attached to the skin of the face and neck by plastic or paper tape.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.