NCT00164866 is a Phase 4 clinical trial of Omeprazole in Peptic Ulcer, sponsored by Chinese University of Hong Kong.

Who is sponsoring NCT00164866?

NCT00164866 is sponsored by Chinese University of Hong Kong.

What drugs are being tested in NCT00164866?

Interventions in NCT00164866: Omeprazole.

What condition does NCT00164866 study?

NCT00164866 studies Peptic Ulcer.

Is NCT00164866 still recruiting?

NCT00164866 is currently completed. Last updated 5 June 2007.

Last reviewed 2007-06-05 · How we verify

NCT00164866

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Administration of Intravenous Proton Pump Inhibitor Prior to Endoscopy [APPE] in Patients With Upper Gastrointestinal Bleeding; a Double-Blind Placebo-Controlled Randomised Study.

Completed Phase 4 Last updated 5 June 2007

What this trial tests

Phase 4 trial testing Omeprazole in Peptic Ulcer in 638 participants. Completed in 1 September 2005.

Timeline

1 February 2004

1 September 2005

Quick facts

Lead sponsor	Chinese University of Hong Kong
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	638
Start date	1 February 2004
Estimated completion	1 September 2005
Sites	1 location across China

Drugs / interventions tested

Omeprazole (omeprazole) — full drug profile →

Conditions studied

Peptic Ulcer — all drugs for Peptic Ulcer →

Sponsor

Chinese University of Hong Kong

Who can join

16 and older, any sex, with Peptic Ulcer. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

early intranvenous infusion of a high-dose poton-pump inhibitor before endoscopy would have a therapeutic effect on bleeding ulcers, reduce the need for endoscopic therapy, and result in improved clinical outcomes.

Sponsor's own description

To evaluate if intravenous PPI infusion, when administered prior to endoscopy, hastens resolution of bleeding stigmata and thereby facilitates endoscopic examinations and reduces the need for endoscopic treatment. Clot stabilization may itself sustain control of bleeding before endoscopy. These may translate into improved patients'outcome and survival. To determine the therapeutic effect of high-dose PPI infusion in upper gastrointestinal bleeding from causes other than peptic ulcers.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Omeprazole before endoscopy in patients with gastrointestinal bleeding.
Lau JY, Leung WK, Wu JC, Chan FK, et al · · 2007 · cited 179× · PMID 17442905 · DOI 10.1056/nejmoa065703
Proton pump inhibitor treatment initiated prior to endoscopic diagnosis in upper gastrointestinal bleeding.
Kanno T, Yuan Y, Tse F, Howden CW, et al · · 2022 · cited 16× · PMID 34995368 · DOI 10.1002/14651858.cd005415.pub4

Verify or expand the search:

Other trials of Omeprazole

Trials testing the same drug.

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NCT07235748 — Drug-drug Interaction Study of Vorasidenib With Bupropion, Repaglinide, Flurbiprofen, Omeprazole, Midazolam, and Rosuvas · Phase 1 · completed
NCT07149415 — A Study to Learn if Taking BIIB141 (Omaveloxolone) Affects How Omeprazole is Processed in the Body and About BIIB141's S · Phase 1 · completed
NCT06948006 — A Study to Investigate the Relative Bioavailability of 2 Different Formulations of AZD4144, the Effect of Food and Omepr · Phase 1 · completed

Other recruiting trials for Peptic Ulcer

Currently open trials in the same condition.

NCT07260006 — Treatment Efficacy of Regimens With and Without Bismuth in Children With Helicobacter Pylori-Associated Peptic Ulcer Dis · NA · recruiting
NCT06284876 — Study to Evaluate the Efficacy and Safety of Ilaprazole 10 mg in Prevention NSAIDs Associated Peptic Ulcer · Phase 3 · recruiting
NCT04702542 — To Develop Methods for the Rehabilitation of Chronic Gastroduodenal Pathology in Children. · NA · active not recruiting

Other Chinese University of Hong Kong trials

Trials by the same sponsor.

NCT07508644 — RSV Vaccination to Reduce Recurrent AECOPD · Phase 4 · not yet recruiting
NCT07230457 — Plasma MTB cfDNA Before Bronchoscopy · not yet recruiting
NCT07288671 — Nostalgia Intervention on Alleviating Loneliness Amongst Older Adults · NA · not yet recruiting
NCT07256457 — Postoperative Pulmonary Function Assessment Based on Deep Learning Study · NA · not yet recruiting
NCT06904209 — Can Artificial Intelligence Reduce Consumption of Standard High Volume Bowel Preparation Regimen Among Older Population, · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00164866 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Chinese University of Hong Kong
Last refreshed: 5 June 2007

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00164866.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing