NCT00159380 is a NA clinical trial of Aminoguanidine in Asthma, sponsored by Imperial College London.

Who is sponsoring NCT00159380?

NCT00159380 is sponsored by Imperial College London.

What drugs are being tested in NCT00159380?

Interventions in NCT00159380: Aminoguanidine, Placebos.

Is NCT00159380 still recruiting?

NCT00159380 is currently completed. Last updated 9 July 2019.

Last reviewed 2019-07-09 · How we verify

NCT00159380

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

A Double Blind, Crossover Placebo-controlled Study to Evaluate the Effect of L-arginine and Aminoguanidine on Bronchial, Alveolar and Nasal NO and NO Metabolites

Completed NA Last updated 9 July 2019

What this trial tests

NA trial testing Aminoguanidine in Asthma in 16 participants. Completed in 1 March 2005.

Timeline

1 September 2003

Primary endpoint
1 March 2005

1 March 2005

Quick facts

Lead sponsor	Imperial College London
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	double
Primary purpose	treatment
Enrollment	16
Start date	1 September 2003
Primary completion	1 March 2005
Estimated completion	1 March 2005
Sites	1 location across United Kingdom

Drugs / interventions tested

Aminoguanidine — full drug profile →
Placebos — full drug profile →

Conditions studied

Asthma — all drugs for Asthma →

Sponsor

Imperial College London

Who can join

Adults 21 to 60, any sex, with Asthma. Healthy volunteers can join.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Bronchial exhale nitric oxide
Time frame: 6 hours
Bronchial exhale nitric oxide (JNo) assessed by chemo luminescence
Peripheral exhaled nitric oxide
Time frame: 6 hours
Peripheral exhaled nitric oxide(CALV) assessed by chemo luminescence

Sponsor's own description

The primary aim of this study is to investigate the effects of oral and inhaled administration of L-arginine and of inhaled aminoguanidine on bronchial and alveolar exhaled NO and NO metabolites in exhaled breath condensate, saliva and nasal lavage fluid in normal and asthmatic subjects.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

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Other Imperial College London trials

Trials by the same sponsor.

NCT06035861 — Endothelial Cell Activation and Total Pulmonary Resistance in PAH · NA · not yet recruiting
NCT07397455 — Development of a Controlled Human Infection Model for Assessment of SARS-CoV-2 Omicron Subvariants · Phase 1 · not yet recruiting
NCT07422532 — A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing · NA · not yet recruiting
NCT07389031 — Maralixibat for Intrahepatic Cholestasis of Pregnancy · Phase 2 · not yet recruiting
NCT07358897 — Gender Affirming Hormone Therapy and Immune Function in Trans Individuals - The GIFT Study · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00159380 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Imperial College London
Last refreshed: 9 July 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00159380.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing