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Pilot, Single-Arm Study of the Effect of Adding Acitretin to Etanercept Therapy in Patients With Moderate to Severe Psoriasis Who Fail to Respond to Etanercept Monotherapy
To determine whether acitretin plus etanercept is more effective than etanercept alone in clearing psoriasis plaques in adults.
Details
| Lead sponsor | University of Medicine and Dentistry of New Jersey |
|---|---|
| Phase | Phase 2 |
| Status | COMPLETED |
| Enrolment | 10 |
| Start date | 2005-09 |
| Completion | 2009-03 |
Conditions
- Psoriasis
Interventions
- acitretin
Primary outcomes
- Percent of Patients Achieving PASI 75 at 6 Months After the Addition of Acitretin Therapy — 6 months
Percentage of participants achieving at least a 75% decrease (improvement) from Baseline in the Psoriasis Area and Severity Index (PASI) at 6 months. PASI Score incorporates measures of erythema, desquamation, infiltration, and affected body surface area. Involvement and severity of psoriasis was scored using a scale of 0 to 72, where 0 = no psoriasis and 72 = severe disease.