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Community-based Helicobacter Pylori Eradication With Two Sequential Antibiotic Regimens for the Residents and Migrants From a High-risk Area for Gastric Cancer
Based on a universal eradication of H. pylori in an offshore island (Matsu) with a high prevalence of gastric cancer as well as premalignant gastric lesion, we first examined the infection rate of H. pylori. Secondly, we evaluated the efficacy of clarithromycin-based triple therapy with a levofloxacin-based rescue treatment. And thirdly, we tested the hypothesis that whether the cure of H. pylori can reverse the premalignant gastric lesion. Fourth, we determine the cost-effectiveness of this intervention. The gene-environment interaction will be addressed regarding gastric cancer carcinogenesis. Finally, the incident rate of gastric cancer would be followed in this cohort.
Details
| Lead sponsor | National Taiwan University Hospital |
|---|---|
| Phase | Phase 4 |
| Status | UNKNOWN |
| Enrolment | 5000 |
| Start date | 2004-01 |
| Completion | 2015-12 |
Conditions
- Helicobacter Pylori Infection
Interventions
- Helicobacter pylori eradication
Primary outcomes
- Successful helicobacter eradication, change in premalignant gastric lesion, and change in gastric cancer incidence rate — 12 years
Countries
Taiwan