NCT00121524 is a Phase 2 clinical trial of Epinephrine in Cardiac Arrest, sponsored by Petter Andreas Steen.

Who is sponsoring NCT00121524?

NCT00121524 is sponsored by Petter Andreas Steen.

What drugs are being tested in NCT00121524?

Interventions in NCT00121524: Epinephrine, Intravenous needle, Atropine, Amiodarone.

What condition does NCT00121524 study?

NCT00121524 studies Cardiac Arrest.

Is NCT00121524 still recruiting?

NCT00121524 is currently completed. Last updated 28 May 2015.

Last reviewed 2015-05-28 · How we verify

NCT00121524

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Epinephrine and I.V. Needle on CPR Outcome

Completed Phase 2 Last updated 28 May 2015

What this trial tests

Phase 2 trial testing Epinephrine in Cardiac Arrest in 904 participants. Completed in 1 June 2008.

Timeline

1 January 2003

Primary endpoint
1 May 2008

1 June 2008

Quick facts

Lead sponsor	Petter Andreas Steen
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	904
Start date	1 January 2003
Primary completion	1 May 2008
Estimated completion	1 June 2008
Sites	1 location across Norway

Drugs / interventions tested

Epinephrine (epinephrine) — full drug profile →
Intravenous needle
Atropine (ATROPINE) — full drug profile →
Amiodarone (AMIODARONE) — full drug profile →

Conditions studied

Cardiac Arrest — all drugs for Cardiac Arrest →

Sponsor

Petter Andreas Steen

Who can join

18 and older, any sex, with Cardiac Arrest. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

survival to hospital discharge with neurologic outcome
Time frame: discharge from hospital

Sponsor's own description

Intravenous epinephrine has been part of the guidelines for cardiopulmonary resuscitation since the start. It improves outcome in animal studies, but has never been investigated in a controlled study in humans. Epidemiologic data indicate that it is an independent negative predictor for survival. If this is true in a controlled randomized study, it could be due to effects of the drug itself or more likely due to reduced quality of chest compressions and ventilations due to the time spent on placing an I.V. needle and injecting drugs.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Intravenous drug administration during out-of-hospital cardiac arrest: a randomized trial.
Olasveengen TM, Sunde K, Brunborg C, Thowsen J, et al · · 2009 · cited 281× · PMID 19934423 · DOI 10.1001/jama.2009.1729

Verify or expand the search:

Other trials of Epinephrine

Trials testing the same drug.

NCT07144267 — Comparison of Milrinone and Epinephrine on TAPSE · NA · not yet recruiting
NCT06284434 — Liposomal Bupivacaine Use in Alveolar Bone Graft Patients · Phase 3 · recruiting
NCT06416969 — Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation · EARLY_PHASE1 · recruiting
NCT05738148 — Vasopressin vs. Epinephrine During Neonatal Cardiopulmonary Resuscitation · Phase 1 · active not recruiting
NCT06013150 — Study of Inhaled DMC-IH1 and Intramuscular (EpiPen®) Epinephrine in Healthy Male and Female Participants. · Phase 1 · completed

Other recruiting trials for Cardiac Arrest

Currently open trials in the same condition.

NCT07239206 — Serious Game for Improving Targeted Temperature Management Knowledge and Situational Awareness in Critical Care Nurses · NA · recruiting
NCT06780722 — Study of the Occurrence of Cardiocirculatory Arrest as a Function of the Level of Hypoxemia During a Maastricht 3 Proced · recruiting
NCT06405581 — The Impact of Frailty on Cardiopulmonary Resuscitation Adverse Outcomes in Patients Requiring Code Blue Activation · recruiting
NCT06511999 — Continuous Jugular Venous Oxygen Saturation (SjO2) Measurement After Cardiac Arrest · recruiting
NCT07113769 — Plasma Biomarkers and Platelet Morphology of Extracorporeal CardioPulmonary Resuscitation · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00121524 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Petter Andreas Steen
Last refreshed: 28 May 2015

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00121524.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing