Fish Oil and Alpha Lipoic Acid in Mild Alzheimer's Disease

NCT00090402 Phase 1/Phase 2 COMPLETED Results posted

The purpose of this study is to determine the effect of fish oil and the antioxidant alpha lipoic acid on factors in the blood that are associated with the progression of Alzheimer's Disease (AD).

Details

Lead sponsor	Oregon Health and Science University
Phase	Phase 1/Phase 2
Status	COMPLETED
Enrolment	39
Start date	2004-04
Completion	2007-08

Conditions

• Alzheimer's Disease
• Oxidative Stress
• Dementia
• Hyperlipidemia
• Inflammation

Interventions

• Fish Oil
• Lipoic Acid
• Fish Oil Placebo
• Lipoic Acid Placebo

Primary outcomes

• F2-isoprostane Level Urine F2-Isoprostanes — baseline, 12 months
  F2-isoprostane is a biomarker was used as an effective indicator for detecting a decrease in systemic oxidative damage (oxidative damage in lipids). Urine F2-Isoprostanes were used to avoid ex vivo lipid peroxidation that can occur with plasma samples.
• Change in Mini-Mental State Exam (MMSE) Score From Baseline to 12 Months — baseline, 12 months
  The MMSE is a measure of global cognitive function, and scores range from 0-30, with a lower score indicates greater cognitive impairment.

Countries

United States