NCT00083499 is a clinical trial in Pentalogy of Cantrell, sponsored by National Heart, Lung, and Blood Institute (NHLBI).

Who is sponsoring NCT00083499?

NCT00083499 is sponsored by National Heart, Lung, and Blood Institute (NHLBI).

What condition does NCT00083499 study?

NCT00083499 studies Pentalogy of Cantrell.

Is NCT00083499 still recruiting?

NCT00083499 is currently completed. Last updated 8 October 2020.

Last reviewed 2020-10-08 · How we verify

NCT00083499

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Mutations in Genes Associated With Pentalogy of Cantrell

Completed Last updated 8 October 2020

What this trial tests

trial in Pentalogy of Cantrell in 59 participants. Completed in 6 September 2019.

Timeline

15 September 2004

Primary endpoint
6 September 2019

6 September 2019

Quick facts

Lead sponsor	National Heart, Lung, and Blood Institute (NHLBI)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	59
Start date	15 September 2004
Primary completion	6 September 2019
Estimated completion	6 September 2019
Sites	2 locations across United States

Conditions studied

Pentalogy of Cantrell — all drugs for Pentalogy of Cantrell →

Sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Who can join

Under 100, any sex, with Pentalogy of Cantrell. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study will collect blood, urine, and other tissue samples from patients with Pentalogy of Cantrell (POC) and other inherited diseases that may involve mutations in non-muscle myosin II-B heavy chain (MYH10). We will also collect samples from the relatives of affected individuals. POC is a very rare disorder in which patients have a combination of severe defects of the middle of the chest including the sternum (breastbone), diaphragm, heart, and abdominal wall. The defect are apparent before birth or at birth. Participants may undergo a medical evaluation that could include a medical history routine blood tests, urine collection, chest x-ray, and electrocardiogram. In addition, blood, urine, saliva, buccal swab or tissue samples may be collected for protein and gene studies. The blood is drawn through a very small needle placed in an arm vein. Children may choose to have a buccal (cheek) sample taken instead of blood draw. Buccal samples can be collected by a cheek swab, in which a soft brush is rubbed on the inside lining of the mouth, or by having the child hold a tablespoon of mouthwash in his or her mouth for a full minute and then spit the mouthwash into a container. In addition, tissue samples may be collected from patients if they undergoing any surgical procedures that may be required as part of their general medical care. Some of the cells obtained from patients or their relatives may be used to establish cell lines (a living tissue sample) that can be grown in the laboratory and used for experiments. ...

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.

Verify or expand the search:

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Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00083499 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Heart, Lung, and Blood Institute (NHLBI)
Last refreshed: 8 October 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00083499.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing