NCT00067119 (GRAFT) is a Phase 3 clinical trial of Aggrenox in Kidney Failure, sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

Who is sponsoring NCT00067119?

NCT00067119 is sponsored by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK).

What drugs are being tested in NCT00067119?

Interventions in NCT00067119: Aggrenox, Placebo.

What condition does NCT00067119 study?

NCT00067119 studies Kidney Failure.

Is NCT00067119 still recruiting?

NCT00067119 is currently completed. Last updated 19 September 2017.

Last reviewed 2017-09-19 · How we verify

NCT00067119: GRAFT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Aggrenox Prevention of Access Stenosis

Completed Phase 3 Last updated 19 September 2017

What this trial tests

Phase 3 trial testing Aggrenox in Kidney Failure in 649 participants. Completed in 31 January 2008.

Timeline

1 January 2003

Primary endpoint
31 January 2008

31 January 2008

Quick facts

Lead sponsor	National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	prevention
Enrollment	649
Start date	1 January 2003
Primary completion	31 January 2008
Estimated completion	31 January 2008
Sites	9 locations across United States

Drugs / interventions tested

Aggrenox — full drug profile →
Placebo

Conditions studied

Kidney Failure — all drugs for Kidney Failure →

Sponsor

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Who can join

18 and older, any sex, with Kidney Failure. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The objective of the study is to determine whether Aggrenox (Boehringer-Ingelheim) prolongs primary unassisted patency in newly created arteriovenous grafts. This record previously included information for both the GRAFT and FISTULA trials.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Effect of clopidogrel on early failure of arteriovenous fistulas for hemodialysis: a randomized controlled trial.
Dember LM, Beck GJ, Allon M, Delmez JA, et al · · 2008 · cited 589× · PMID 18477783 · DOI 10.1001/jama.299.18.2164
Effect of dipyridamole plus aspirin on hemodialysis graft patency.
Dixon BS, Beck GJ, Vazquez MA, Greenberg A, et al · · 2009 · cited 189× · PMID 19458364 · DOI 10.1056/nejmoa0805840

Verify or expand the search:

Other recruiting trials for Kidney Failure

Currently open trials in the same condition.

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NCT06243731 — A Study of Maribavir in Adults With Kidney Failure Who Have a Cytomegalovirus (CMV) Infection After Transplantation · recruiting
NCT06642597 — STarting incrEmental Prescription of Peritoneal Dialysis · NA · recruiting
NCT06343727 — A High Protein Egg White Pudding for People With Kidney Failure (HiPE KF) · NA · recruiting
NCT07053462 — CRISPR-Edited HLA Donor Kidney Transplant to Reduce Rejection Risk · Phase 1, PHASE2 · recruiting

Other National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) trials

Trials by the same sponsor.

NCT07313787 — Effects of Meal Macronutrients on Postprandial Lipids · Phase 2 · not yet recruiting
NCT07388537 — Evaluation of the Clinical Spectrum of Diabetes and Obesity in Youth and Adults · not yet recruiting
NCT05713799 — Trial of the Combination of Alpha-Lipoic Acid and Mirabegron in Women and in Men With Obesity · Phase 2 · not yet recruiting
NCT05722210 — Prevalence and Development of Liver Dysfunction in Hematopoietic Stem Cell Transplant · not yet recruiting
NCT07191561 — Hepatic Lipid Metabolism-Alcohol Use Disorder · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT00067119 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Last refreshed: 19 September 2017

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT00067119.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing