Last reviewed · How we verify
Prevention of Maternal to Infant HIV Transmission in India (SWEN)
Infants who are breast-fed by HIV infected mothers have an increased risk of becoming infected with HIV. Standard therapy for the prevention of HIV infections in infants included zidovudine (ZDV) prior to the onset of labor, a single dose of nevirapine (NVP) for women during labor, and a single dose of NVP for newborns given 72 hours after birth. This study will determine if giving low dose daily NVP to breastfed infants of HIV infected mothers, in addition to standard therapy, will be more effective than standard therapy alone at preventing HIV infections in these infants.
Details
| Lead sponsor | National Institute of Allergy and Infectious Diseases (NIAID) |
|---|---|
| Phase | Phase 3 |
| Status | COMPLETED |
| Enrolment | 770 |
| Start date | 2002-08 |
| Completion | 2007-09 |
Conditions
- HIV Infections
Interventions
- Nevirapine and mulitvitamins
Primary outcomes
- HIV infection rate of infants — 6 months of age
- Safety of the regimens for HIV-infected mothers and their breast-fed infants — Through 12 months post-partum
Countries
India