NCT00034424

Cause of Familial Testicular Cancer

Completed Last updated 17 April 2026

What this trial tests

trial in Testicular Cancer in 749 participants. Completed.

Timeline

13 January 2003

Quick facts

Lead sponsor	National Cancer Institute (NCI)
Status	Completed
Study type	OBSERVATIONAL
Enrollment	749
Start date	13 January 2003
Sites	1 location across United States

Conditions studied

• Testicular Cancer — all drugs for Testicular Cancer →

Sponsor

National Cancer Institute (NCI)

Who can join

Adults 12 to 77, any sex, with Testicular Cancer. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

People with a family history of testicular cancer may be at increased risk for the disease.

Genetic and clinical studies of patients with testicular cancer and their family members may help clarify the cause of the disease and identify clinical features.

Objectives:

To characterize the clinical features of testicular cancer.

To identify genes that may lead to increased risk of the disease.

To examine emotional and behavioral issues of members of families at increased risk of the disease.

Eligibility:

Males and females from a family with at least two cases of testicular cancer in blood relatives.

Males with testicular cancer in both testicles.

Males with testicular cancer who have an identical twin.

Participants must be at least 12 years of age.

Design:

Participants may take part in Part 1 or Parts 1 and 2 of this 2-part study.

Part 1 participants:

* Provide a blood or cheek cell sample to obtain DNA for gene studies.
* Provide permission for researchers to obtain their medical records for review.
* Complete questionnaires about their personal and family medical history, exposure to factors that might influence the risk of testicular cancer, and their feelings about being a member of a family in which several members have testicular cancer.
* These data are collected from participants in their home communities.

Part 2 participants:

* All participants provide a medical history, have a complete physical examination, including routine lab tests, and have an ultrasound test of the abdomen to look at the kidneys.
* Males have an ultrasound test of the testicles and scrotum.
* Females have an ultrasound test of the pelvis to look at the ovaries, uterus and fallopian tubes.
* Males 18 years of age and older provide a semen sample.
* Some participants have computed tomography (CT) scanning of the chest, abdomen and pelvis instead of kidney ultrasound. Children under 18 years of age may have magnetic resonance imaging (MRI) instead of CT.
* These data are collected from participants during a 2-day visit to the NIH Clinical Center in Bethesda, MD. Travel costs are covered by the protocol.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.