NCT00013533

Pilot Study of Non-Myeloablative, HLA-Matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies

Completed EARLY_PHASE1 Last updated 16 December 2019

What this trial tests

EARLY_PHASE1 trial testing Stem cell transplantation in Hodgkin Lymphoma in 30 participants. Completed in 7 May 2015.

Timeline

14 March 2001

Primary endpoint
1 March 2008

7 May 2015

Quick facts

Lead sponsor	National Cancer Institute (NCI)
Phase	EARLY_PHASE1
Status	Completed
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	treatment
Enrollment	30
Start date	14 March 2001
Primary completion	1 March 2008
Estimated completion	7 May 2015
Sites	1 location across United States

Drugs / interventions tested

• Stem cell transplantation — full drug profile →

Conditions studied

• Hodgkin Lymphoma — all drugs for Hodgkin Lymphoma →
• Lymphocytic Leukemia — all drugs for Lymphocytic Leukemia →
• Mixed Cell Leukemia — all drugs for Mixed Cell Leukemia →
• Myelodysplastic Syndrome — all drugs for Myelodysplastic Syndrome →

Sponsor

National Cancer Institute (NCI)

Who can join

Adults 4 to 20, any sex, with Hodgkin Lymphoma or Lymphocytic Leukemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Background:

* Allogeneic blood and marrow stem cell transplantation (BMT) plays an important role in the curative treatment of a number of pediatric malignancies. Unfortunately, the success of conventional allogeneic BMT is limited in part by the multiple toxicities associated with myeloablative preparative regimens.
* Non-myeloablative pre-transplant regimens are associated with less toxic side effects than standard BMT. Recently, a novel immunosuppressive, non-myeloablative pre-transplant chemotherapy regimen has been shown to facilitate complete donor engraftment in an adult trial at the NCI.

Objectives:

The primary objective of this protocol is to evaluate the efficacy and safety of this treatment approach in pediatric patients with hematopoietic malignancies

Eligibility:

Inclusion Criteria

Age: Patient must be greater than or equal to 5 years and less than 22 years of age.

Diagnosis:

* Hodgkin s and Non-Hodgkin s Lymphoma: Refractory disease or relapse after salvage regimen.
* Acute Myelogenous Leukemia: History of bone marrow relapse in remission (CR) #2 or greater.
* Acute Lymphocytic Leukemia: History of bone marrow relapse in CR #2 or greater (CR#1 with Philadelphia chromosome positive or prior induction failure).
* Acute Hybrid Leukemia including mixed lineage, biphenotypic and undifferentiated: History of bone marrow relapse in CR #2 or greater (CR#1 with Philadelphia chromosome positive or prior induction failure).
* Myelodysplastic Syndrome: RAEB or RAEB-t with less than 10% blasts in marrow and blood.
* Chronic Myelogenous Leukemia: Chronic phase or accelerated phase with less than 10% blasts in marrow and blood.
* Juvenile Myelomonocytic Leukemia: less than 10% blasts in marrow and blood.

Prior Therapy: Chemotherapy to achieve above criteria allowed. Prior BMT allowed as long as at least day 100+ post-prior BMT, no evidence of GVHD, and no detectable residual donor chimerism.

Donor: First degree related donors, who are HLA matched (single HLA-A or B locus mismatch allowed), weight greater than or equal to 15 kilograms, and who meet standard donation criteria will be considered. The same donor from a prior BMT is allowed.

ECOG Performance Status: 0, 1, or 2. and life expectancy: greater than 3 months.

Liver Function: Serum direct bilirubin less than 2.0 mg/dL and serum ALT and AST values less than or equal to 2.5x upper limit of normal. (Values above these levels may be accepted if due to malignancy.)

Renal Function: Age adjusted normal serum creatinine or Cr clearance greater than or equal to 60 mL/min/1.73 m(2).

Pulmonary Function: DLCO greater than or equal to 50%.

Cardiac Function: LVEF greater than or equal to 45% by MUGA or LVSF greater than or equal to 28% by ECHO

Exclusion Criteria

* Active CNS malignancy: Tumor mass on CT or leptomeningeal disease. (Patients with a history of CNS involvement and no current evidence of CNS disease are allowed.)
* HIV infection, active hepatitis B or C infection: HbSAg or HCV seropositive and elevated liver transaminases.
* Fanconi Anemia.
* Lactating or pregnant females.

Design:

Pilot Study

* Initial evaluation: Patient and donor will be screened for eligibility. G-CSF primed bone marrow derived stem cells will be collected from the donor.
* Induction/Consolidation chemotherapy: 1 to 3 cycles will be given every 22 days depending on disease response, CD4 count, and toxicities.
* Lymphoma: fludarabine, etoposide, doxorubicin, vincristine, cyclophohamide, prednisone, and filgrastim (EPOCH-fludarabine).
* Leukemia and MDS: Fludarabine, cytarabine, and filgrastim (FLAG).
* Transplantation: Fludarabine and cyclophosphamide will be administered over 4 days followed by bone marrow transplant. Patients will remain hospitalized until bone marrow recovery. Patients will be monitored closely at the NIH for at least 100 days post-BMT.
* Post-transplant CNS prophylaxis for ALL: Standard post-transplant CNS prophylaxis will be employed with intrathecal methotrexate to decrease the risk of CNS relapse for all patients with ALL.
* Total number of recipient and donors to be accrued is 56.

Publications & conference data

No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.