Phase III Randomized Trial of Sequential High-Dose Chemotherapy Versus Standard Chemotherapy for the Treatment of Small Cell Lung Cancer

NCT00011921 Phase 3 UNKNOWN

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Giving chemotherapy with peripheral stem cell transplant or bone marrow transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. It is not yet known whether high-dose chemotherapy plus peripheral stem cell or bone marrow transplant is more effective than chemotherapy alone in treating small cell lung cancer. PURPOSE: This randomized phase III trial is studying how well chemotherapy followed by peripheral stem cell or bone marrow transplant works compared to chemotherapy alone in treating patients with limited-stage or extensive-stage small cell lung cancer.

Details

Lead sponsor	EBMT Solid Tumors Working Party
Phase	Phase 3
Status	UNKNOWN
Enrolment	430
Start date	1997-09

Conditions

• Lung Cancer

Interventions

• filgrastim
• carboplatin
• epirubicin hydrochloride
• etoposide
• etoposide phosphate
• ifosfamide
• paclitaxel
• autologous bone marrow transplantation
• bone marrow ablation with stem cell support
• peripheral blood stem cell transplantation

Primary outcomes

• Overall survival (OS) at 3 years

Countries

Switzerland