A Phase III Comparison of Biafine to Declared Institutional Preference for Radiation Induced Skin Toxicity in Patients Undergoing Radiation Therapy for Advanced Squamous Cell Carcinomas of the Head and Neck

NCT00006481 Phase 3 COMPLETED

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells, but may cause skin irritation and inflammation. Biafine cream may be effective in lessening side effects caused by radiation therapy. PURPOSE: Randomized phase III trial to determine the effectiveness of Biafine cream in reducing side effects of radiation therapy in patients receiving treatment for head and neck cancer.

Details

Lead sponsor	Radiation Therapy Oncology Group
Phase	Phase 3
Status	COMPLETED
Start date	2000-10

Conditions

• Head and Neck Cancer
• Skin Reactions Secondary to Radiation Therapy

Interventions

• Biafine cream
• quality-of-life assessment
• radiation therapy

Countries

United States, Canada