PFL-Alpha Chemotherapy Followed by Surgery or FHX for Early Stage Esophageal Cancer - A Pilot Project

NCT00004897 Phase 2 TERMINATED

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining more than one drug and combining chemotherapy with interferon alfa, surgery, and/or radiation therapy may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy and interferon alfa followed by surgery and/or radiation therapy in treating patients who have stage I, stage II, or stage III esophageal cancer.

Details

Lead sponsor	Northwestern University
Phase	Phase 2
Status	TERMINATED
Start date	1999-10
Completion	2007-11

Conditions

• Esophageal Cancer

Interventions

• recombinant interferon alfa
• cisplatin
• fluorouracil
• hydroxyurea
• leucovorin calcium
• conventional surgery
• radiation therapy

Countries

United States